Endocrine Abstracts

Objective: Acromegaly is characterized by chronic hypersecretion of growth hormone (GH) with increased concentration of IGF-1. There have been controversial debates over the question whether elevated GH levels indicate high risk of developing colorectal neoplasm. There is no clear guideline indicating the need for colorectal cancer screening for acromegalics. We evaluated the colonoscopic findings in our series of patients to analyze the prevalence of risk. Should patients wit...

Objective: Acromegaly is characterized by chronic hypersecretion of growth hormone (GH) with increased concentration of IGF-1. It is known that patients with acromegaly have a high risk of developing cardiovascular diseases. We evaluated vascular changes by performing echodoppler ultrasonography in our series of patients.Methods: Ultrasonographywas performed on 10 patients within one week after transsphenoidal surgery. The study includes 6 male and 4 fem...

Objective: Gastroenteropancreatic neuroendocrine neoplasm (GEP-NENs) are rare and heterogeneous in their tumor biology. Therapeutic options to prevent growth and dissemination are still not satisfactory. As shown previously, survivin and aurora kinases (members of the mitotic chromosomal passenger complex) play a role in cell cycle progression; FOXM1 is a transcription factor that regulates G2/M progression and is associated with grading and metastasis in GEP-NENs. Aurora kina...